A systematic review of the effects of adding neostigmine to local anesthetics for neuraxial administration in obstetric anesthesia and analgesia. Issue 3 (August 2015) - Cossu, A.P.
Highlights We reviewed the neuraxial use of neostigmine in obstetric anaesthesia and analgesia. Neuraxial neostigmine as an adjuvant affords a reduction in local anaesthetic dose. Intrathecal but not epidural neostigmine increases the risk of nausea. Neuraxial neostigmine does not compromise maternal hemodynamic stability. Neuraxial neostigmine as an adjuvant appears to be safe for the fetus.