The brown fat secretome: metabolic functions beyond thermogenesis. (May 2015)

• Record Type: Journal Article
• Authors: Wang, Guo-Xiao; Zhao, Xu-Yun; Lin, Jiandie D.
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 5(2015)
• Page Start: 231
• Page End: 237
• Publication Date: 2015-05
• Subjects: Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2015.03.002
• Languages: English
• ISSNs: 1043-2760

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Brown fat contributes to systemic metabolism via thermogenesis-dependent and -independent mechanisms.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The brown fat secretome incudes Nrg4, FGF21, and BMPs, among others.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The brown fat secretome may coordinate metabolic adaptation during thermogenesis.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Developing novel therapies based on brown fat thermogenesis may target the extracellular factors released by brown fat.</p> </list-item> </list> </p> </sec> </abstract>