Fumonisin B1 inhibits apoptosis in HepG2 cells by inducing Birc-8/ILP-2. Issue 2 (1st June 2015)

• Record Type: Journal Article
• Authors: Chuturgoon, Anil A.; Phulukdaree, Alisa; Moodley, Devapregasan
• Is Part Of: Toxicology letters. Volume 235:Issue 2(2015)
• Page Start: 67
• Page End: 74
• Publication Date: 2015-06-01
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.03.006
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0030"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Fumonisin B₁ (FB₁) inhibits apoptosis in HepG2 liver cells.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">FB₁ significantly up-regulated the anti-apoptotic Birc-8/ILP-2 gene and protein expression.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">FB₁ significantly decreased phosphorylated γH2AX and cleaved PARP in HepG2 cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">FB₁ decreased expression of Smac/DIABLO.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">FB₁ modulates apoptosis in a complex dose dependent regulation of pro-and anti-apoptotic molecules.</p> </list-item> </list> </p> </sec> </abstract>