Vitamin D status and risk of metabolic syndrome among non-diabetic young adults. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Huang, Chiao-Yu; Chang, Hao-Hsiang; Lu, Chia-Wen; Tseng, Fen-Yu; Lee, Long-Teng; Huang, Kuo-Chin
• Is Part Of: Clinical nutrition. Volume 34:Issue 3(2015:Jun.)
• Page Start: 484
• Page End: 489
• Publication Date: 2015-06
• Subjects: Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2014.05.010
• Languages: English
• ISSNs: 0261-5614

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Background and aims</title> <p id="abspara0010">Low vitamin D status has been linked to obesity, insulin resistance, and metabolic syndrome. In the present study, we aimed to explore the nature and strength of the relationship between vitamin D and metabolic syndrome among non-diabetic young adults.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">This was a campus-based cross-sectional study of 355 non-diabetic young adult graduate students (233 males and 132 females; mean age, 23.5 ± 2.4 years) in Northern Taiwan. We measured and tested the association of serum 25-hydroxyvitamin D levels with metabolic syndrome and cardio-metabolic parameters.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">A total of 24 (6.8%) recruited young adults had metabolic syndrome. There were decreasing trends of body mass index (BMI), Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) and prevalence of metabolic syndrome across increasing tertiles of vitamin D levels irrespective of age and sex (<italic>P</italic> for trend <0.05). Without adjusting for BMI or HOMA-IR, the odds of having metabolic syndrome decreased across increasing tertiles of vitamin D levels (<italic>P</italic> for trend 0.021). The odds ratio of having metabolic syndrome was 0.26 (95% confidence interval: 0.08–0.85, <italic>P</italic> = 0.025) for the highest <italic>vs.</italic> the lowest tertile of vitamin D levels. However, further adjustments for BMI and HOMA-IR largely removed the inverse association of vitamin D status with metabolic syndrome and its individual components.</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">Among non-diabetic young adults, the potential inverse relationship between vitamin D status and metabolic syndrome may be attributable to the conjunctive effects of individual obesity and insulin resistance.</p> </sec> </abstract>