Restoration of the anti-proliferative and anti-migratory effects of 1, 25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells. Issue 2 (1st July 2015)

• Record Type: Journal Article
• Authors: Bhatia, Vandanajay; Falzon, Miriam
• Is Part Of: Cancer letters. Volume 362:Issue 2(2015)
• Page Start: 199
• Page End: 207
• Publication Date: 2015-07-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.042
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">HT-29 cells were used as a model system for the intestinal epithelial.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">TNF-α increased Snail1 and Slug levels, and decreased vitamin D receptor levels.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">The TNF-α effects were reversed by the flavonolignan silibinin.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">HT-29 cells are resistant to 1, 25D's anti-proliferative and anti-migratory effects.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Co-treatment with silibinin rendered HT-29 cells responsive to 1, 25D.</p> </list-item> </list> </p> </sec> </abstract>