17β-Estradiol and natural progesterone for menopausal hormone therapy: REPLENISH phase 3 study design of a combination capsule and evidence review. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Mirkin, Sebastian; Amadio, Julia M.; Bernick, Brian A.; Pickar, James H.; Archer, David F.
• Is Part Of: Maturitas. Volume 81:Issue 1(2015:May)
• Page Start: 28
• Page End: 35
• Publication Date: 2015-05
• Subjects: Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2015.02.266
• Languages: English
• ISSNs: 0378-5122

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">No combination natural estradiol/progesterone capsule is FDA or EMA approved.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">REPLENISH studies a natural estradiol/progesterone capsule (TX-001HR).</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Various doses of TX-001HR are being evaluated for treating hot flushes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Safety outcomes differ among types of estrogens and among types of progestogens.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">TX-001HR may be a safer hormone therapy option vs existing hormone therapies.</p> </list-item> </list> </p> </sec> </abstract>