Autophagy in malignant transformation and cancer progression. (23rd February 2015)

• Record Type: Journal Article
• Authors: Galluzzi, Lorenzo; Pietrocola, Federico; Bravo‐San Pedro, José Manuel; Amaravadi, Ravi K; Baehrecke, Eric H; Cecconi, Francesco; Codogno, Patrice; Debnath, Jayanta; Gewirtz, David A; Karantza, Vassiliki; Kimmelman, Alec; Kumar, Sharad; Levine, Beth; Maiuri, Maria Chiara; Martin, Seamus J; Penninger, Josef; Piacentini, Mauro; Rubinsztein, David C; Simon, Hans‐Uwe; Simonsen, Anne; Thorburn, Andrew M; Velasco, Guillermo; Ryan, Kevin M; Kroemer, Guido
• Is Part Of: EMBO journal. Volume 34:Number 7(2015)
• Page Start: 856
• Page End: 880
• Publication Date: 2015-02-23
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201490784
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="embj201490784-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Autophagy has been described to have tumor‐suppressive as well as tumor‐promoting functions. This review discusses how stage and context alters the role for autophagy in cancer, and argues for further research prior to targeting autophagy in cancer therapy.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjjn18z1c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>