Creating cellular diversity through transcription factor competition. (13th February 2015)

• Record Type: Journal Article
• Authors: Göttgens, Berthold
• Is Part Of: EMBO journal. Volume 34:Number 6(2015)
• Page Start: 691
• Page End: 693
• Publication Date: 2015-02-13
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201591017
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201591017-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">The development of blood cells has long served as a model system to study the generation of diverse mature cells from multipotent progenitors. The article by Org <italic>et al</italic> (2015) reveals how transcription factor competition on primed DNA templates may contribute to embryonic blood cell specification during the early stages of mesoderm development. The study not only provides new insights into the functionality of the key haematopoietic transcription factor Scl/Tal1, but also provides a potentially widely applicable framework for transcription factor‐mediated cell fate specification.</p> </abstract>