Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. (7th January 2015)

• Record Type: Journal Article
• Authors: Org, Tõnis; Duan, Dan; Ferrari, Roberto; Montel‐Hagen, Amelie; Van Handel, Ben; Kerényi, Marc A; Sasidharan, Rajkumar; Rubbi, Liudmilla; Fujiwara, Yuko; Pellegrini, Matteo; Orkin, Stuart H; Kurdistani, Siavash K; Mikkola, Hanna KA
• Is Part Of: EMBO journal. Volume 34:Number 6(2015)
• Page Start: 759
• Page End: 777
• Publication Date: 2015-01-07
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201490542
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="embj201490542-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Previous work had revealed that Scl promotes hemogenic competence while repressing cardiac fate. Comprehensive genome‐scale data presented here establish Scl‐mediated 'enhancer decommissioning' as underlying molecular mechanism. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjjn18p5k" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>