Changed in translation: mRNA recoding by −1 programmed ribosomal frameshifting. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Caliskan, Neva; Peske, Frank; Rodnina, Marina V.
• Is Part Of: Trends in biochemical sciences. Volume 40:Issue 5(2015)
• Page Start: 265
• Page End: 274
• Publication Date: 2015-05
• Subjects: Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2015.03.006
• Languages: English
• ISSNs: 0968-0004

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">–1PRF occurs when ribosomes move over a slippery sequence.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">A frameshifting pseudoknot/stem-loop element stalls ribosomes in a metastable state.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">–1PRF may contribute to the quality-control machinery in eukaryotes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020"> <italic>Trans</italic>-acting factors (proteins, miRNAs, or antibiotics) can modulate –1PRF.</p> </list-item> </list> </p> </sec> </abstract>