Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2, 3, 5, 6, 7, 8-hexahydroisoquinolins as potential EZH2 inhibitors. Issue 33 (12th April 2015)

• Record Type: Journal Article
• Authors: Zhang, Lidan; Song, Xuejiao; Wang, Ningyu; Zhao, Lifeng; Feng, Qiang; You, Xinyu; Peng, Cuiting; Gao, Tiantao; Xiong, Menghua; He, Bing; Gao, Chao; Luo, Yong; Xu, Ying; Zhang, Qiyi; Yu, Luoting
• Is Part Of: RSC advances. Volume 5:Issue 33(2015)
• Page Start: 25967
• Page End: 25978
• Publication Date: 2015-04-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra02365c
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjjh2959r" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />This study led to the discovery of several potent compounds with low nanomolar to sub-nanomolar potency for EZH2.</p> </abstract>