When to Initialize Enteral Nutrition in Patients With Severe Acute Pancreatitis?. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Wu, Xing-Mao; Liao, Yu-Wei; Wang, Hai-Yuan; Ji, Kai-Qiang; Li, Guo-Fu; Zang, Bin
• Is Part Of: Pancreas. Volume 44:Issue 3(2015)
• Publication Date: 2015-04
• Subjects: Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000293
• Languages: English
• ISSNs: 0885-3177

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>The present retrospective study aimed to analyze the optimal time to initiate enteral nutrition (EN) in patients with severe acute pancreatitis at a single Chinese institution (China Medical University Hospital).</p> </sec> <sec> <title>Methods</title> <p>A total of 1196 patients with severe acute pancreatitis were admitted in the intensive care unit between November 2003 and June 2013; 1092 patients were selected and were divided into the early and delayed EN groups, according to their initial timing of EN.</p> </sec> <sec> <title>Results</title> <p>Five hundred sixty-six patients were administered with the delayed EN, and 526 with the early EN. Both groups had similar severity of pancreatic necrosis, but organ failure developed in 81% patients of the delayed EN group and 21% in the early EN group (<italic>P</italic> &lt; 0.01). The numbers of septic necrosis and morbidity were significantly higher in the delayed EN group than in the early EN (<italic>P</italic> &lt; 0.01).</p> </sec> <sec> <title>Conclusions</title> <p>The early EN had significant benefits over the delayed EN in the decrease of organ failure and mortality; our findings suggested that the first 48 hours of administration in the intensive care unit was the optimal time to start EN.</p> </sec> </abstract>