Plasma Aldosterone Concentration Is Positively Associated With Pulse Pressure in Patients With Primary Hypertension. Issue 10 (March 2015)

• Record Type: Journal Article
• Authors: Yao, Xiaoguang; Li, Nanfang; Zhang, Yujie; Zhang, Juhong; Abulikm, Suofeiya; Zhang, Delian; Chang, Guijuan; Zhou, Keming; Kong, Jianqiong; Lymperopoulos., Anastasios
• Is Part Of: Medicine. Volume 94:Issue 10(2015)
• Publication Date: 2015-03
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000614
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Increasing evidence showed a link between arterial elasticity and stiffness and pulse pressure (PP), in which plasma aldosterone may play a role. The observational study aimed to explore the potential relations between plasma aldosterone concentration (PAC) and PP in patients with hypertension.</p> <p>We evaluated the relation between PP and PAC in supine, seated, and upright positions in 195 patients with primary hypertension who underwent postural stimulation test. They were divided into 3 groups by tertiles of PP: PP ⩽ 44 mm Hg (n = 70), 44 mm Hg < PP ⩽ 51 mm Hg (n = 63), and PP ≥ 51 mm Hg (n = 62). The PAC in different postures was compared, respectively.</p> <p>The results showed the following. First, segregated by tertiles of PP, serum K<sup>+</sup>, 24-hour systolic blood pressure, 24-hour diastolic blood pressure, sex, upright PAC, and seated PAC showed statistically significant differences in groups. Second, the PAC were significantly different in 3 levels of PP regardless of postures, the individuals with PP ≥ 51 mm Hg had the highest PAC. On contrast, the patients with PAC > 12 ng/dL showed greater PP than those with PAC ⩽ 12 ng/dL. Third, weak associations between PP and upright (<italic>r</italic> = 0.288, <italic>P</italic> < 0.001), seated (<italic>r</italic> = 0.265, <italic>P</italic> < 0.001), and supine postures (<italic>r</italic> = 0.191, <italic>P</italic> = 0.008) were detected by simple correlation analysis. After corrected serum K<sup>+</sup>, age, and sex, the partial correlation coefficients did not change greatly. Fourth, the logistic regression model was constructed with PP ≥ 40 mm Hg or PP < 40 mm Hg as the dependent variable; the serum K<sup>+</sup>[OR = 0.043, 95% CI: 1.09(1.00–1.12)] and PAC [OR = 0.025, 95%CI: 0.35(0.13–0.88)] were included as significant contributing factors.</p> <p>The results showed that higher PAC was weakly, but significantly, correlated to greater PP regardless of different postures, suggesting that higher PAC may be a risk factor of reduced arterial elasticity in patients with hypertension.</p> </sec> </abstract>