Serum carboxymethyl-lysine, an advanced glycation end product, is associated with arterial stiffness in older adults. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Semba, Richard D.; Sun, Kai; Schwartz, Ann V.; Varadhan, Ravi; Harris, Tamara B.; Satterfield, Suzanne; Garcia, Melissa; Ferrucci, Luigi; Newman, Anne B.
• Is Part Of: Journal of hypertension. Volume 33:Issue 4(2015:Apr.)
• Publication Date: 2015-04
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000000460
• Languages: English
• ISSNs: 1473-5598

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective:</title> <p>The objective of this study is to examine the relationship of serum carboxymethyl-lysine (CML), an advanced glycation end product (AGE), with pulse pressure (PP), aortic pulse wave velocity (aPWV) and hypertension in older adults.</p> </sec> <sec> <title>Background:</title> <p>AGEs are bioactive molecules that accumulate in tissues with ageing and can both cross-link collagen and induce inflammation in model systems. The relationship of AGEs with arterial stiffness and hypertension has not been well characterized in community-dwelling older adults.</p> </sec> <sec> <title>Methods:</title> <p>We measured serum CML and blood pressure in 3044 adults, aged 70–79 years, who participated in the Health, Aging and Body Composition Study, a population-based study of ageing in Pittsburgh, Pennsylvania and Memphis, Tennessee. aPWV was measured in 2468 participants.</p> </sec> <sec> <title>Results:</title> <p>Participants in the highest tertile of serum CML had higher PP (highest tertile: beta = 2.85, SE = 0.82, <italic>P</italic> = 0.0005; middle tertile: beta = 0.60, SE = 0.80, <italic>P</italic> = 0.45), and higher aPWV (highest tertile: beta = 51.4, SE = 20.1, <italic>P</italic> = 0.01; middle tertile: beta = 3.2, SE = 19.8, <italic>P</italic> = 0.87) than those in the lowest tertile in multivariable linear regression models adjusting for age, sex, race, education, BMI, smoking, alcohol use, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes, cardiovascular disease and chronic kidney disease. Participants in the highest and middle tertiles of serum CML had higher odds of hypertension [odds ratio (OR) 1.32, 95% confidence interval (95% CI) 1.06–1.60, <italic>P</italic> = 0.005; OR 1.27, 95% CI 1.05–1.53, <italic>P</italic> = 0.01, respectively] than those in the lowest tertile in a multivariable logistic regression model adjusting for the same covariates.</p> </sec> <sec> <title>Conclusion:</title> <p>Elevated serum CML was associated with arterial stiffness, as reflected by higher PP and aPWV, in older, community-dwelling adults.</p> </sec> </abstract>