PPI-responsive esophageal eosinophilia cannot be distinguished from eosinophilic esophagitis by endoscopic signs. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Warners, Marijn J.; van Rhijn, Bram D.; Curvers, Wouter L.; Smout, Andreas J.P.M.; Bredenoord, Albert J.
• Is Part Of: European journal of gastroenterology & hepatology. Volume 27:Issue 5(2015:May)
• Publication Date: 2015-05
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000000331
• Languages: English
• ISSNs: 0954-691X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background</title> <p>Eosinophilic esophagitis (EoE) is a chronic antigen-mediated disease histologically characterized by eosinophil-predominant inflammation. One-third of patients respond to proton pump inhibitor (PPI) treatment; this group is identified as having PPI-responsive esophageal eosinophilia (PPI-REE). If we could predict the response to PPIs on the basis of endoscopic signs, futile treatment efforts and additional endoscopies to assess treatment response can be prevented.</p> </sec> <sec> <title>Objective</title> <p>To determine whether endoscopic signs can distinguish PPI-REE from EoE.</p> </sec> <sec> <title>Methods</title> <p>Endoscopic images of 30 EoE and 30 PPI-REE patients were included. Baseline characteristics were compared between groups. Complete clinical remission after a PPI trial for at least 8 weeks was classified as PPI-REE. Per patient, at least three depersonalized images were incorporated into a slideshow. These images were scored by two experienced endoscopists according to a validated classification system.</p> </sec> <sec> <title>Results</title> <p>Characteristics were highly comparable between EoE and PPI-REE patients. Endoscopic signs were similar and did not enable differentiation between EoE and PPI-REE [presence of: rings (<italic>P</italic>=0.893), white exudates <italic>(P</italic>=0.209), furrows (<italic>P</italic>=0.371), edema (<italic>P</italic>=0.554), crepe paper esophagus (<italic>P</italic>=1.000), and strictures (<italic>P</italic>=0.071)].</p> </sec> <sec> <title>Conclusion</title> <p>Endoscopic signs at baseline endoscopy cannot distinguish EoE from PPI-REE before a PPI trial; the demographic and clinical characteristics in both groups are similar. Endoscopic features do not enable differentiation between PPI-REE and EoE.</p> </sec> </abstract>