Initial Experience Using 99mTc-MIBI SPECT/CT for the Differentiation of Oncocytoma From Renal Cell Carcinoma. (April 2015)

• Record Type: Journal Article
• Authors: Rowe, Steven P.; Gorin, Michael A.; Gordetsky, Jennifer; Ball, Mark W.; Pierorazio, Phillip M.; Higuchi, Takahiro; Epstein, Jonathan I.; Allaf, Mohamad E.; Javadi, Mehrbod S.
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 4(2015)
• Publication Date: 2015-04
• Subjects: Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000670
• Languages: English
• ISSNs: 0363-9762

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Purpose</title> <p>The differentiation of oncocytoma from renal cell carcinoma (RCC) remains a challenge with currently available cross-sectional imaging techniques. As a result, a large number of patients harboring a benign oncocytoma undergo unnecessary surgical resection. In this study, we explored the utility of ^99mTc-MIBI SPECT/CT for the differentiation of these tumors based on the hypothesis that the large number of mitochondria in oncocytomas would lead to increased ^99mTc-MIBI uptake.</p> </sec> <sec> <title>Patients and Methods</title> <p>In total, 6 patients (3 with oncocytoma and 3 with RCC) were imaged with ^99mTc-MIBI SPECT/CT. Relative quantification was performed by measuring tumor-to-normal renal parenchyma background ratios.</p> </sec> <sec> <title>Results</title> <p>All 3 oncocytomas demonstrated radiotracer uptake near or above the normal renal parenchymal uptake (range of uptake ratios, 0.85–1.78). In contrast, the 3 RCCs were profoundly photopenic relative to renal background (range of uptake ratios, 0.21–0.31).</p> </sec> <sec> <title>Conclusions</title> <p> ^99mTc-MIBI SPECT/CT appears to be of value in scintigraphically distinguishing benign renal oncocytoma from RCC.</p> </sec> </abstract>