Prognostic factors after surgical resection of N1 non-small cell lung cancer. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Mordant, P.; Pricopi, C.; Legras, A.; Arame, A.; Foucault, C.; Dujon, A.; Le Pimpec-Barthes, F.; Riquet, M.
• Is Part Of: European journal of surgical oncology. Volume 41:Issue 5(2015:May)
• Page Start: 696
• Page End: 701
• Publication Date: 2015-05
• Subjects: Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2014.10.003
• Languages: English
• ISSNs: 0748-7983

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objectives</title> <p id="abspara0010">Non-small cell lung carcinoma (NSCLC) with N1 involvement is associated with 5-year survival rates ranging from 7% to 55%. Numerous factors have been independently reported to explain this heterogeneous prognosis, but their relative weight on long-term survival is unknown.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">Patients who underwent surgical resection for NSCLC in two French centers from 1993 to 2010 were prospectively recorded and retrospectively reviewed. The overall survival (OS) of patients undergoing first-line surgery for pN1 disease was analyzed according to the type of extension, number of metastatic LN, number and anatomic location of metastatic stations.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">The study group included 450 patients (male 80.2%, mean age 63.3 ± 9.9 years, 5-year overall survival 46%). The number of metastatic station was 1 in 340 (75.6%, single-station disease) and ≥2 in 110 patients (24.4%, multi-station disease). The number of metastatic stations was correlated with the number of metastatic LN (<italic>p</italic> < .001), and associated with adverse OS (<italic>p</italic> = .0014). The presence of intralobar metastatic LN (station 12–13–14) was associated with a mechanism of direct extension (<italic>p</italic> < .001), but did not impact OS (<italic>p</italic> = .71). The location of metastatic stations was of prognostic significance only in case of multi-station disease, with hilar (station 10) involvement being associated with adverse OS (<italic>p</italic> = .005). The 110 patients with multi-station pN1 disease and the 134 patients operated on for single-station pN0N2 (skip-N2) disease during the study period yield comparable outcome (<italic>p</italic> = .52).</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">In patients with resected pN1 NSCLC, the number of metastatic stations and their location in case of multi-station disease have a prognostic value.</p> </sec> </abstract>