Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: Evaluation of concordance between genomic and transcriptional profiles. Issue 7 (May 2015)

• Record Type: Journal Article
• Authors: Vignot, Stéphane; Lefebvre, Céline; Frampton, Garrett M.; Meurice, Guillaume; Yelensky, Roman; Palmer, Gary; Capron, Frédérique; Lazar, Vladimir; Hannoun, Laurent; Miller, Vincent A.; André, Fabrice; Stephens, Philip J.; Soria, Jean-Charles; Spano, Jean-Philippe
• Is Part Of: European journal of cancer. Volume 51:Issue 7(2015:May)
• Page Start: 791
• Page End: 799
• Publication Date: 2015-05
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2015.02.012
• Languages: English
• ISSNs: 0959-8049

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st055">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0120">Intratumoural heterogeneity represents a major challenge for precision medicine.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0125">Molecular variability was investigated in 13 metastatic colorectal cancer patients.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0130">Mutational and gene expression (GE) analysis were performed.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0135">Profile of primary tumour can identify key somatic alterations in matched metastases.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0140">GE identified specific pathways associated in metastatic progression.</p> </list-item> </list> </p> </sec> </abstract>