The effect of chronic kidney disease on the urine proteome in the domestic cat (Felis catus). Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Ferlizza, E.; Campos, A.; Neagu, A.; Cuoghi, A.; Bellei, E.; Monari, E.; Dondi, F.; Almeida, A.M.; Isani, G.
• Is Part Of: Veterinary journal. Volume 204:Issue 1(2015)
• Page Start: 73
• Page End: 81
• Publication Date: 2015-04
• Subjects: Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2015.01.023
• Languages: English
• ISSNs: 1090-0233

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Chronic kidney disease is a major cause of mortality in cats, but sensitive and specific biomarkers are currently lacking.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">This study aimed to apply proteomic techniques to map the cat urine proteome and compare it with that in cats with CKD.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Our work produced a reference map of the normal cat urine proteome containing 20 proteins identified by mass spectrometry.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">We identified 13 proteins differentially represented in CKD.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Most of these proteins are indicative of tubulointerstitial damage when not reabsorbed or not secreted.</p> </list-item> </list> </p> </sec> </abstract>