Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: A microarray study. Issue 1 (April 2015)

• Record Type: Journal Article
• Authors: Lu, C.-C.; Liu, M.-M.; Culshaw, G.; Clinton, M.; Argyle, D.J.; Corcoran, B.M.
• Is Part Of: Veterinary journal. Volume 204:Issue 1(2015)
• Page Start: 23
• Page End: 31
• Publication Date: 2015-04
• Subjects: Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2015.02.021
• Languages: English
• ISSNs: 1090-0233

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Microarrays were used to analyse transcript changes in canine myxomatous mitral valve disease (MMVD).</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">In total, 591 differentially expressed genes were identified with 322 up-regulated and 269 down-regulated.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Data suggest contribution of endothelial-to-mesenchymal transition to disease pathogenesis.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Data will allow for hypothesis-driven research to understand MMVD.</p> </list-item> </list> </p> </sec> </abstract>