Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Lin, Xiaojing; Fang, Qin; Chen, Shuya; Zhe, Nana; Chai, Qixiang; Yu, Meisheng; Zhang, Yaming; Wang, Ziming; Wang, Jishi
• Is Part Of: Leukemia research. Volume 39:Issue 5(2015:May)
• Page Start: 544
• Page End: 552
• Publication Date: 2015-05
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.02.009
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Heme oxygenase-1 (HO-1) is aberrantly overexpressed in the majority of AML patients.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">HO-1 has an effect on the apoptosis of AML cell lines.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Overexpression of HO-1 accelerates leukemia's progression in vivo.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">HO-1 suppresses the apoptosis of AML cells through activating JNK/c-JUN signaling pathway.</p> </list-item> </list> </p> </sec> </abstract>