First results of the preoperative accelerated partial breast irradiation (PAPBI) trial. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: van der Leij, Femke; Bosma, Sophie C.J.; van de Vijver, Marc J.; Wesseling, Jelle; Vreeswijk, Sandra; Rivera, Sofia; Bourgier, Celine; Garbay, Jean-Rémi; Foukakis, Theodoros; Lekberg, Tobias; van den Bongard, Desiree H.J.G.D.; van Vliet-Vroegindeweij, Corine; Bartelink, Harry; Rutgers, Emiel J.; Elkhuizen, Paula H.M.
• Is Part Of: Radiotherapy and oncology. Volume 114:Issue 3(2015:Mar.)
• Page Start: 322
• Page End: 327
• Publication Date: 2015-03
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.02.002
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st150">Abstract</title> <sec> <title id="st105">Background and purpose</title> <p id="sp0005">The aim of this study is to assess the toxicity and cosmetic outcome of preoperative accelerated partial breast irradiation (PAPBI) for breast cancer patients with low risk on local recurrence.</p> </sec> <sec> <title id="st110">Material and methods</title> <p id="sp0010">Women aged ⩾60 years with an invasive, unifocal ⩽3 cm on MRI, (non-lobular) adenocarcinoma of the breast and a negative sentinel node received PAPBI (40 Gray in 10 fractions over 2 weeks). Six weeks after radiotherapy a wide local excision was performed.</p> </sec> <sec> <title id="st115">Results</title> <p id="sp0015">70 patients with a median follow-up of 23 months (3–44 months) were evaluated. The overall postoperative infection rate was 11%. At 1, 2 and 3 years of follow-up respectively 89%, 98% and 100% of patients had no or mild induration-fibrosis. Fibrosis was only found in a small volume of the breast. The global cosmetic outcome was good to excellent in 77% at 6 months to 100% at 3 years. Two patients developed a local recurrence.</p> </sec> <sec> <title id="st120">Conclusion</title> <p id="sp0020">Our first results show limited fibrosis in a small volume and good to excellent cosmetic outcome. In selected patients, preoperative radiotherapy appears to be a good option for breast conserving therapy.</p> </sec> </abstract>