Charged particle therapy versus photon therapy for patients with hepatocellular carcinoma: A systematic review and meta-analysis. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Qi, Wei-Xiang; Fu, Shen; Zhang, Qing; Guo, Xiao-Mao
• Is Part Of: Radiotherapy and oncology. Volume 114:Issue 3(2015:Mar.)
• Page Start: 289
• Page End: 295
• Publication Date: 2015-03
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2014.11.033
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st055">Abstract</title> <sec> <title id="st060">Purpose</title> <p id="sp0005">To perform a systematic review and meta-analysis to compare the clinical outcomes and toxicity of hepatocellular carcinoma (HCC) patients treated with charged particle therapy (CPT) with those of individuals receiving photon therapy.</p> </sec> <sec> <title id="st065">Methods</title> <p id="sp0010">We identified relevant clinical studies through searching databases. Primary outcomes of interest were overall survival (OS) at 1, 3, 5 years, progression-free survival (PFS), and locoregional control (LC) at longest follow-up.</p> </sec> <sec> <title id="st070">Results</title> <p id="sp0015">73 cohorts from 70 non-comparative observational studies were included. Pooled OS was significantly higher at 1, 3, 5 years for CPT than for conventional radiotherapy (CRT) [relative risk (RR) 1·68, 95% CI 1·22–2·31; <italic>p</italic> < 0·001; RR 3.46, 95% CI: 1.72–3.51, <italic>p</italic> < 0.001; RR 25.9, 95% CI: 1.64–408.5, <italic>p</italic> = 0.02; respectively]. PFS and LC at longest follow-up was also significantly higher for CPT than for CRT (<italic>p </italic>= 0·013 and <italic>p </italic>< 0.001, respectively), while comparable efficacy was found between CPT and SBRT in terms of OS, PFS and LC at longest follow-up. Additionally, high-grade acute and late toxicity associated with CPT was lower than that of CRT and SBRT.</p> </sec> <sec> <title id="st075">Conclusion</title> <p id="sp0020">Survival rates for CPT are higher than those for CRT, but similar to SBRT in patients with HCC. Toxicity tends to be lower for CPT compared to photon radiotherapy.</p> </sec> </abstract>