Wnt/β-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Issue 1 (28th June 2015)

• Record Type: Journal Article
• Authors: Leung, Wilson K.C.; He, Mian; Chan, Anthony W.H.; Law, Priscilla T.Y.; Wong, Nathalie
• Is Part Of: Cancer letters. Volume 362:Issue 1(2015)
• Page Start: 97
• Page End: 105
• Publication Date: 2015-06-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.023
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">miR-183/96/182 upregulation predicts shorter recurrence free survival in HCC patients.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Functionally, miR-183, -96 and -182 promotes cellular invasion and migration of HCC cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">MiR-183, -96 and -182 concomitantly and directly targets FOXO1 3′ untranslated region.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Over-expression of miR-183, -96 and -182 is caused by β-catenin activation in HCC.</p> </list-item> </list> </p> </sec> </abstract>