Gene expression profiles of circulating tumor cells versus primary tumors in metastatic breast cancer. Issue 1 (28th June 2015)

• Record Type: Journal Article
• Authors: Onstenk, Wendy; Sieuwerts, Anieta M.; Weekhout, Marleen; Mostert, Bianca; Reijm, Esther A.; van Deurzen, Carolien H.M.; Bolt-de Vries, Joan B.; Peeters, Dieter J.; Hamberg, Paul; Seynaeve, Caroline; Jager, Agnes; de Jongh, Felix E.; Smid, Marcel; Dirix, Luc Y.; Kehrer, Diederik F.S.; van Galen, Anne; Ramirez-Moreno, Raquel; Kraan, Jaco; Van, Mai; Gratama, Jan W.; Martens, John W.M.; Foekens, John A.; Sleijfer, Stefan
• Is Part Of: Cancer letters. Volume 362:Issue 1(2015)
• Page Start: 36
• Page End: 44
• Publication Date: 2015-06-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.020
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">In 62 metastatic breast cancer (MBC) patients with ≥5 CTCs starting first-line treatment.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Expression levels of 35 CTC-specific genes were compared with primary tumors.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">In 48% we observed large discordance between primary tumor and CTCs.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">In 24% expression of the estrogen receptor was discordant.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Discordance in ER had prognostic significance, whereas overall discordance had not.</p> </list-item> </list> </p> </sec> </abstract>