Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism. Issue 1 (28th June 2015)

• Record Type: Journal Article
• Authors: Shim, Joong Sup; Li, Ruo-Jing; Lv, Junfang; Head, Sarah A.; Yang, Eun Ju; Liu, Jun O.
• Is Part Of: Cancer letters. Volume 362:Issue 1(2015)
• Page Start: 106
• Page End: 115
• Publication Date: 2015-06-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.022
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Selective estrogen receptor modulators (SERM) inhibited cholesterol trafficking in endothelial cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">SERM caused abnormal subcellular localizations of VEGFR2 and mTOR in endothelial cells.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">SERM inhibited VEGFR2 and mTOR signaling pathways in endothelial cells.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Inhibition of angiogenesis by SERM was cholesterol-dependent, but ER-independent.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Cholesterol trafficking in endothelial cells is a novel target for inhibition of angiogenesis and cancer.</p> </list-item> </list> </p> </sec> </abstract>