REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A–JAK2/STAT3 positive feedback loop. Issue 1 (28th June 2015)

• Record Type: Journal Article
• Authors: Liu, Xiulan; Wang, Jun; Wang, Hongjie; Yin, Guoxiao; Liu, Yang; Lei, Xiang; Xiang, Ming
• Is Part Of: Cancer letters. Volume 362:Issue 1(2015)
• Page Start: 45
• Page End: 60
• Publication Date: 2015-06-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.014
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab9010"> <title id="st9010">Highlights</title> <sec> <p id="sp9010"> <list id="ulist9010"> <list-item id="u9010"> <label></label> <p id="p9010">We demonstrate the exact network associated with REG3A signaling contributed to inflammation-related pancreatic cancer.</p> </list-item> <list-item id="u9015"> <label></label> <p id="p9015">We report that a REG3A-JAK2/STAT3 positive feedback loop presented in the activation of REG3A by binding with EGFR.</p> </list-item> <list-item id="u9020"> <label></label> <p id="p9020">We determine that REG3A in synergy with IL-6 markedly triggered pancreatic cancer cells proliferation and tumorigenesis.</p> </list-item> </list> </p> </sec> </abstract>