ADAM protease inhibitors reduce melanogenesis by regulating PMEL17 processing in human melanocytes. Issue 2 (May 2015)

• Record Type: Journal Article
• Authors: Kawaguchi, Masakazu; Hozumi, Yutaka; Suzuki, Tamio
• Is Part Of: Journal of dermatological science. Volume 78:Issue 2(2015:May)
• Page Start: 133
• Page End: 142
• Publication Date: 2015-05
• Subjects: Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2015.02.020
• Languages: English
• ISSNs: 0923-1811

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Melanin content was reduced by the treatment with ADAM protease inhibitor.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The number of mature melanosomes was reduced by the treatment with ADAM protease inhibitor.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">ADAM protease inhibitor acted on the processing of PMEL17 as γ-secretase and BACE2-independently.</p> </list-item> </list> </p> </sec> </abstract>