Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: A prospective cohort study. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Rebnord, Eirik Wilberg; Pedersen, Eva Ringdal; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Meyer, Klaus; Schartum-Hansen, Hall; Løland, Kjetil Halvorsen; Seifert, Reinhard; Ueland, Per Magne; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Nygård, Ottar
• Is Part Of: Atherosclerosis. Volume 240:Issue 1(2015)
• Page Start: 115
• Page End: 120
• Publication Date: 2015-05
• Subjects: Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.02.053
• Languages: English
• ISSNs: 0021-9150

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objective</title> <p id="abspara0010">Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c to long-term prognosis in such patients.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">A prospective cohort of 2519 patients undergoing elective coronary angiography for suspected stable angina pectoris (SAP) was divided into pre-defined categories according to HbA1c (%) levels (<5.0, 5.0–5.6 (reference), 5.7–6.4), and followed for median 4.9 years. The primary end-point was major coronary events (including non-fatal and fatal acute myocardial infarctions, and sudden cardiac death). Secondary end-points were death from cardiovascular disease (CVD) and all-cause mortality. Hazard ratios (HRs) (95% confidence intervals [CIs]) were obtained by Cox regression.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Median age at inclusion was 62 years, 73% were males, median HbA1c was 5.6% and random plasma-glucose 5.4 mmol/L. After multivariate adjustment, HbA1c levels within the pre-diabetic range were not associated with risk of major coronary events, HR (95% CI): 1.13 (0.79–1.62); P = 0.49, death from CVD or all-cause mortality HR (95% CI): 0.95 (0.55–1.66) and 1.04 (0.70–1.53), respectively; P ≥ 0.85. Similarly, there was no significant association between HbA1c values within the lowest category and risk of study outcomes, (P ≥ 0.18).</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">In non-diabetic patients with suspected SAP, there was no overall association between HbA1c levels and prognosis, questioning an independent role of glycemia in the pathogenesis of atherosclerotic complications in these patients.</p> </sec> </abstract>