Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Fizelova, Maria; Miilunpohja, Manna; Kangas, Antti J.; Soininen, Pasi; Kuusisto, Johanna; Ala-Korpela, Mika; Laakso, Markku; Stančáková, Alena
• Is Part Of: Atherosclerosis. Volume 240:Issue 1(2015)
• Page Start: 272
• Page End: 277
• Publication Date: 2015-05
• Subjects: Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.03.034
• Languages: English
• ISSNs: 0021-9150

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objective</title> <p id="abspara0010">We investigated the association of various lipoprotein traits, apolipoproteins and their ratios with the deterioration of glycemia, incident type 2 diabetes, insulin resistance and insulin secretion in a large population-based Metabolic Syndrome Men (METSIM) Study.</p> </sec> <sec> <title id="sectitle0020">Research design and methods</title> <p id="abspara0015">The METSIM Study includes 10, 197 Finnish men, aged 45–73 years, and examined in 2005–2010. From 6607 non-diabetic participants without statin treatment at baseline, 386 developed incident type 2 diabetes during a 5.9-year follow-up. A total of 3330 non-diabetic participants without statin treatment had both baseline and follow-up visit data, and were included in statistical analyses of the worsening of glycemia.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Compared to single lipid and lipoprotein measurements, lipoprotein and apolipoprotein ratios were better predictors of the glucose area under the curve and incident type 2 diabetes after adjustment for confounding factors. The apolipoprotein B/LDL cholesterol ratio was the strongest predictor of the worsening of glycemia, whereas the apolipoprotein A1/HDL cholesterol ratio was the strongest predictor of incident type 2 diabetes. The associations of lipoprotein traits, apolipoproteins and their ratios with insulin sensitivity were stronger than those with insulin secretion.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">The apolipoprotein B/LDL cholesterol and apolipoprotein A1/HDL cholesterol ratios were the strongest predictors of the worsening of glycemia and incident type 2 diabetes, respectively.</p> </sec> </abstract>