Cyclosporin A upregulates ETB receptor in vascular smooth muscle via activation of mitogen-activating protein kinases and NF-κB pathways. Issue 1 (19th May 2015)

• Record Type: Journal Article
• Authors: Zheng, Jian-Pu; Cheng, Zhuoan; Jiang, Jiaye; Ke, Yan; Liu, Zongjun
• Is Part Of: Toxicology letters. Volume 235:Issue 1(2015)
• Page Start: 1
• Page End: 7
• Publication Date: 2015-05-19
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.03.004
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0025"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Cyclosporin A (CsA) enhances ET_B receptor upregulation (at mRNA, protein, and functional levels) in VSMC.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">CsA induces phosphorylation of ERK1/2 and p38 MAPK, and NF-κB translocation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Inhibition of MAPK/NF-κB attenuates CsA-enhanced upregulation of ET_B receptor.</p> </list-item> </list> </p> </sec> </abstract>