Factors associated with a poor response to gefitinib in the NEJ002 study: Smoking and the L858R mutation. Issue 2 (May 2015)

• Record Type: Journal Article
• Authors: Fukuhara, Tatsuro; Maemondo, Makoto; Inoue, Akira; Kobayashi, Kunihiko; Sugawara, Shunichi; Oizumi, Satoshi; Isobe, Hiroshi; Gemma, Akihiko; Harada, Masao; Yoshizawa, Hirohisa; Kinoshita, Ichiro; Fujita, Yuka; Saijo, Yasuo; Hagiwara, Koichi; Morita, Satoshi; Nukiwa, Toshihiro
• Is Part Of: Lung cancer. Volume 88:Issue 2(2015:May)
• Page Start: 181
• Page End: 186
• Publication Date: 2015-05
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.02.004
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">EGFR-TKI treatment for NSCLC with EGFR mutation shows high response rate and long PFS.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">But several cases showed poor response.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">In NEJ002 study, 8.2% cases were showed no response to the gefitinib treatment.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Heavy smoking and the L858R mutation may be related to poor response.</p> </list-item> </list> </p> </sec> </abstract>