Clinical and prognostic implications of RET rearrangements in metastatic lung adenocarcinoma patients with malignant pleural effusion. Issue 2 (May 2015)

• Record Type: Journal Article
• Authors: Tsai, Tzu-Hsiu; Wu, Shang-Gin; Hsieh, Min-Shu; Yu, Chong-Jen; Yang, James Chih-Hsin; Shih, Jin-Yuan
• Is Part Of: Lung cancer. Volume 88:Issue 2(2015:May)
• Page Start: 208
• Page End: 214
• Publication Date: 2015-05
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.02.018
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We screened <italic>RET</italic>-rearranged NSCLC using multiplex RT-PCR for 722 effusion samples.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Seventeen (2.4%) <italic>KIF5B</italic>–<italic>RET</italic> and <italic>CCDC6</italic>–<italic>RET</italic> fusions were detected, including two novel variants.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Presence of <italic>RET</italic> rearrangements was not associated with age, sex, or smoking history.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Solid histologic subtype accounted for the majority of <italic>RET</italic>-rearranged tumors.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025"> <italic>RET</italic>-rearranged NSCLC conferred favorable survival comparable to <italic>EGFR</italic>-mutant tumors.</p> </list-item> </list> </p> </sec> </abstract>