Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression. Issue 2 (May 2015)

• Record Type: Journal Article
• Authors: Mao, Kaisheng; Liu, Fakeng; Liu, Xiuju; Khuri, Fadlo R.; Marcus, Adam I.; Li, Mingsong; Zhou, Wei
• Is Part Of: Lung cancer. Volume 88:Issue 2(2015:May)
• Page Start: 131
• Page End: 138
• Publication Date: 2015-05
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.02.017
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">LKB1 is not a mediator of paclitaxel-induced apoptosis in non-small cell lung cancers.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Restoration of wild-type LKB1 in LKB1-mutant EKVX cells leads to the overexpression of MDR1 and paclitaxel resistance.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The expression of LKB1 correlates with class III β-tubulin expression in EKVX and H1299 cells.</p> </list-item> </list> </p> </sec> </abstract>