Comparison of bone marrow versus peripheral blood allogeneic hematopoietic stem cell transplantation for hematological malignancies in adults—a systematic review and meta-analysis. Issue 2 (May 2015)

• Record Type: Journal Article
• Authors: Holtick, Udo; Albrecht, Melanie; Chemnitz, Jens M.; Theurich, Sebastian; Shimabukuro-Vornhagen, Alexander; Skoetz, Nicole; Scheid, Christof; von Bergwelt-Baildon, Michael
• Is Part Of: Critical reviews in oncology/hematology. Volume 94:Issue 2(2015)
• Page Start: 179
• Page End: 188
• Publication Date: 2015-05
• Subjects: Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2014.12.007
• Languages: English
• ISSNs: 1040-8428

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Peripheral blood stem cells have replaced bone marrow as main stem cell source in the last two decades.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Transplant indications, conditioning regimens and donor selection criteria have clearly changed in the last 10–15 years.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">It is under debate, whether transplant outcomes might be influenced by the choice of the stem cell source against the background of current transplant settings.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">This systematic review demonstrates that the current clinical standard to use peripheral blood stem cells instead of bone marrow for allo-SCT is not inferior with regard to the primary outcome overall survival although graft-versus-host disease is increased.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Data must be collected analysing more recently treated patients with regard to reduced-intensity and mismatch transplants as well as transplants of elderly patients.</p> </list-item> </list> </p> </sec> </abstract>