Analysis of WNT4 polymorphism in Chinese Han women with endometriosis. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Wu, Zhangying; Yuan, Ming; Li, Yan; Fu, Fangfang; Ma, Wenqinq; Li, Haixia; Wang, Wenwen; Wang, Shixuan
• Is Part Of: Reproductive biomedicine online. Volume 30:Issue 4(2015)
• Page Start: 415
• Page End: 420
• Publication Date: 2015-04
• Subjects: Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2014.12.010
• Languages: English
• ISSNs: 1472-6483

Abstract

<abstract abstract-type="author" id="ab0010"> <title id="st0010">Abstract</title> <sec> <p id="sp0010">Endometriosis is a complex disease that is influenced by genetic and environmental factors. In endometriosis, WNT4 plays a likely role owing to its biological functions. In this study, the TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single nucleotide polymorphisms in <italic>WNT4</italic> (rs7521902 [A/C], rs16826658 [G/T], rs7515106 [C/T] and rs2235529 [A/G]) in Chinese Han women. A total of 646 patients with endometriosis and 766 normal controls were recurited. Regression analyses revealed that rs2235529 was a risk locus for endometriosis (<italic>P</italic> = 1.80E-03, OR, 95% CI = 1.311, 1.129 to 1.522), particularly in patients with stage III and IV disease. No significant association was found between endometriosis and rs7521902 (A/C), rs16826658 (G/T), or rs7515106 (C/T). For each of the four single nucleotide polymorphisms, no association was found between patients with endometriosis-related infertility or primary infertility and the controls. The results demonstrated that <italic>WNT4</italic> rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.</p> </sec> </abstract>