Child apolipoprotein E gene variants and risk of cerebral palsy: Estimation from case–parent triads. (May 2015)

• Record Type: Journal Article
• Authors: Stoknes, Magne; Lien, Espen; Andersen, Guro L.; Bao, Yongde; Blackman, James A.; Lie, Rolv Terje; Vik, Torstein
• Is Part Of: European journal of paediatric neurology. Volume 19:Number 3(2015:May)
• Page Start: 286
• Page End: 291
• Publication Date: 2015-05
• Subjects: Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2014.12.017
• Languages: English
• ISSNs: 1090-3798

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objective</title> <p id="abspara0010">To use case–parent triad data to investigate if cerebral palsy (CP) is associated with variants of the <italic>APOE</italic> gene, the rs59007384 SNP of the <italic>TOMM40</italic> gene or combined haplotypes of the two genes.</p> </sec> <sec> <title id="sectitle0020">Study design</title> <p id="abspara0015">DNA was analyzed in buccal swabs from 235 children with CP, their parents and a sibling. The relative risks (RR) with 95% confidence intervals (CI) that the children would have a distribution of <italic>APOE</italic> genotypes, rs59007384 variants or combined haplotypes deviating from Mendelian inheritance were estimated.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Children with CP were more likely than expected to carry the <italic>APOE</italic>ε3 allele (RR 7.5; CI: 0.99–53.7 for heterozygotes and 10.3; CI: 1.4–79.6 for homozygotes), and to have the haplotype of <italic>APOE</italic>ε3 and rs59007384 G (RR 2.4; CI: 1–5.7 for heterozygotes, RR 3.7; CI: 1.4–9.5 for homozygotes) whereas the distribution was as expected for rs59007384 alone. In the subgroup analyses the findings were confined to children born preterm. Among siblings the distribution of these genes was as expected according to Mendelian inheritance.</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">We speculate that children with <italic>APOE</italic>ε2/<italic>APOE</italic>ε4 alleles are more likely to die following cerebral injury in utero, resulting in a higher than expected proportion of children with CP carrying the <italic>APOE</italic>ε3 allele.</p> </sec> </abstract>