Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes. Issue 4 (June 2015)

• Record Type: Journal Article
• Authors: Scherzad, Agmal; Hackenberg, Stephan; Schramm, Carolin; Froelich, Katrin; Ginzkey, Christian; Hagen, Rudolf; Kleinsasser, Norbert
• Is Part Of: Toxicology in vitro. Volume 29:Issue 4(2015)
• Page Start: 813
• Page End: 818
• Publication Date: 2015-06
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.01.018
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st095">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0155">Salinomycin induces cytotoxic effects in human non-malignant cells at 20 μM.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0160">Genotoxic potential was not found.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0165">The secretion of IL-8 was attenuated at sub-toxic concentrations.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0170">Toxicity occurs at concentrations relevant for cancer stem cell therapy.</p> </list-item> </list> </p> </sec> </abstract>