A comparison of the effects of tributyltin chloride and triphenyltin chloride on cell proliferation, proapoptotic p53, Bax, and antiapoptotic Bcl-2 protein levels in human breast cancer MCF-7 cell line. Issue 4 (June 2015)

• Record Type: Journal Article
• Authors: Fickova, Maria; Macho, Ladislav; Brtko, Julius
• Is Part Of: Toxicology in vitro. Volume 29:Issue 4(2015)
• Page Start: 727
• Page End: 731
• Publication Date: 2015-06
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.02.007
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st075">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0120">Tributyltin chloride (TBT) and triphenyltin chloride (TPT) were tested.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0125">TBT is more effective than TPT in inhibiting growth of MCF7 breast cancer cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0130">TBT markedly enhanced p53 protein expression by time and dose dependent manner.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0135">TBT and TPT have similar mild stimulatory effects on Bax protein expression.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0140">TPT rapidly and sharply inhibits Bcl-2 protein expression during 24 h interval.</p> </list-item> </list> </p> </sec> </abstract>