Deconjugation of soy isoflavone glucuronides needed for estrogenic activity. Issue 4 (June 2015)

• Record Type: Journal Article
• Authors: Islam, M.A.; Bekele, R.; vanden Berg, J.H.J.; Kuswanti, Y.; Thapa, O.; Soltani, S.; van Leeuwen, F.X.R.; Rietjens, I.M.C.M.; Murk, A.J.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 4(2015)
• Page Start: 706
• Page End: 715
• Publication Date: 2015-06
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.01.013
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st105">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0150">Genistein and diadzein glucuronides (GG and DG) are not estrogenic.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0155">Deconjugation of GG and DG to their corresponding aglycones renders them estrogenic.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0160">The slight estrogenic activity of GG and DG in vitro is the result of intracellular deconjugation.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0165">At realistic plasma concentrations of the SIF breast cancer cell proliferation was inhibited.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0170">Deconjugation of GG and DG by rat S9 is 30 times faster than by human breast tissue S9.</p> </list-item> </list> </p> </sec> </abstract>