Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47. Issue 4 (June 2015)

• Record Type: Journal Article
• Authors: Yeh, Andrew; Kruse, Shane E.; Marcinek, David J.; Gallagher, Evan P.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 4(2015)
• Page Start: 672
• Page End: 680
• Publication Date: 2015-06
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2015.01.015
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab010"> <title id="st120">Highlights</title> <sec> <p id="sp0045"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0165">BDE 47 is a toxic PBDE flame retardant and major contaminant in Pacific salmon.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0170">Oxidized omega-3 fatty acids (oxEPA/oxDHA) partially prevented BDE 47 toxicity.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0175">oxEPA/oxDHA partially protected viability and mitochondrial membrane potential.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0180">oxEPA/oxDHA partially protected mitochondrial electron transport system function.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0185">Our results indicate oxEPA/oxDHA protects against shorter exposures to BDE 47.</p> </list-item> </list> </p> </sec> </abstract>