Type I IFN – A blunt spear in fighting HIV-1 infection. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Acchioni, Chiara; Marsili, Giulia; Perrotti, Edvige; Remoli, Anna Lisa; Sgarbanti, Marco; Battistini, Angela
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 2(2015)
• Page Start: 143
• Page End: 158
• Publication Date: 2015-04
• Subjects: Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2014.10.004
• Languages: English
• ISSNs: 1359-6101

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">HIV-1 components can effectively trigger an innate immune response through various Pattern Recognition Receptors.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">IFN is produced early during HIV-1 infection, but this initial response is dampened by viral escape mechanisms.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Immune clearance is prevented and the virus replicates and spreads, while establishing a persistent infection.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Prolonged and sustained stimulation of IFN during the chronic phase of infection drives chronic immune activation and inflammation.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Chronic immune activation and inflammation contribute to the immunopathogenesis of progressive HIV-1 disease.</p> </list-item> </list> </p> </sec> </abstract>