Divergent effects of type-I interferons on regulatory T cells. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Piconese, Silvia; Pacella, Ilenia; Timperi, Eleonora; Barnaba, Vincenzo
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 2(2015)
• Page Start: 133
• Page End: 141
• Publication Date: 2015-04
• Subjects: Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2014.10.012
• Languages: English
• ISSNs: 1359-6101

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Conflicting data exist about type-I IFNs playing pro- or anti-Treg activities.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">IFNs may induce alternative suppressor T cells such as Tr1 and FoxA1+ Treg.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Some IRFs regulate Treg functions, even if the link with IFN response is unclear.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">IFN therapy may reduce Treg in the short term but expand Treg in the long term.</p> </list-item> </list> </p> </sec> </abstract>