MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2. Issue 3 (5th May 2015)

• Record Type: Journal Article
• Authors: Zhang, Pu; Bai, Huiyuan; Liu, Gentao; Wang, Heyong; Chen, Feng; Zhang, Baoshun; Zeng, Panying; Wu, Chengxiang; Peng, Cong; Huang, Changjin; Song, Yang; Song, Erqun
• Is Part Of: Toxicology letters. Volume 234:Issue 3(2015)
• Page Start: 151
• Page End: 161
• Publication Date: 2015-05-05
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.02.018
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0035"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">EF24 suppressed melanoma migration and EMT.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">EF24 increased miR-33b expression and subsequently inhibited HMGA2 expression.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">EF24 suppressed melanoma EMT by targeting miR-33b.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">miR-33b knockdown or HMGA2 overexpression reverted EF24-mediated suppression of FAK, Src and RhoA activation.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">miR-33b knockdown or HMGA2 overexpression reverted inhibitory effect of EF24 on stress fiber formation.</p> </list-item> </list> </p> </sec> </abstract>