Disintegration of cruciform and G-quadruplex structures during the course of helicase-dependent amplification (HDA). Issue 8 (15th April 2015)

• Record Type: Journal Article
• Authors: Li, Dawei; Lv, Bei; Zhang, Hao; Lee, Jasmine Yiqin; Li, Tianhu
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 8(2015)
• Page Start: 1709
• Page End: 1714
• Publication Date: 2015-04-15
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.02.070
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st015">Graphical abstract</title> <sec> <p id="sp0005">It is demonstrated in our studies that positive supercoiling generated in HDA reaction can act as the driving force to disintegrate the cruciform and G-quadruplex structures. <fig id="f0025" position="anchor"><graphic position="anchor" xlink:href="ark:/27927/pgjcxv9tc9" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></fig></p> </sec> </abstract>