FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer. Issue 2 (1st June 2015)

• Record Type: Journal Article
• Authors: Zhang, Zhen; Yang, Chao; Gao, Wei; Chen, Tuanhui; Qian, Tingting; Hu, Jun; Tan, Yongjun
• Is Part Of: Cancer letters. Volume 361:Issue 2(2015)
• Page Start: 240
• Page End: 250
• Publication Date: 2015-06-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.008
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">This study confirms the role of FOXA2 in preventing EMT and metastasis of breast cancer.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">FOXA2 prevents EMT by stimulating E-cadherin transcription and repressing ZEB2 via recruiting TLE3 to ZEB2 promoter.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">The upregulation of FOXA2 could be a therapeutic approach for metastasis of breast cancer.</p> </list-item> </list> </p> </sec> </abstract>