Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment. Issue 2 (1st June 2015)

• Record Type: Journal Article
• Authors: Almendros, Isaac; Gileles-Hillel, Alex; Khalyfa, Abdelnaby; Wang, Yang; Zhang, Shelley X.; Carreras, Alba; Farré, Ramon; Gozal, David
• Is Part Of: Cancer letters. Volume 361:Issue 2(2015)
• Page Start: 233
• Page End: 239
• Publication Date: 2015-06-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.03.010
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist9010"> <list-item id="u0010"> <label></label> <p id="p0010">Sleep apnea is characterized by intermittent hypoxia (IH), and is associated with adverse cancer outcomes.</p> </list-item> <list-item id="u9015"> <label></label> <p id="p9015">IH-induced changes in TAMs contribute to increased tumor proliferation and invasion in mice.</p> </list-item> <list-item id="u9020"> <label></label> <p id="p9020">Adipose tissue macrophages show differential polarization under IH, depending on the presence or absence of tumor.</p> </list-item> <list-item id="u9025"> <label></label> <p id="p9025">Increased Tregs in the ipsilateral adipose tissue to the tumor may contribute to alter polarity of macrophages toward M2 phenotype.</p> </list-item> </list> </p> </sec> </abstract>