Variation of growth in the production of the BCG vaccine and the association with the immune response. An observational study within a randomised trial. Issue 17 (21st April 2015)

• Record Type: Journal Article
• Authors: Biering-Sørensen, Sofie; Jensen, Kristoffer Jarlov; Aamand, Susanne Havn; Blok, Bastiaan; Andersen, Andreas; Monteiro, Ivan; Netea, Mihai G.; Aaby, Peter; Benn, Christine Stabell; Hasløv, Kaare Robert
• Is Part Of: Vaccine. Volume 33:Issue 17(2015)
• Page Start: 2056
• Page End: 2065
• Publication Date: 2015-04-21
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.02.056
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The production of live BCG vaccine is subject to variation in bacterial growth rate.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Slow growing BCG was associated with higher frequency of scars and PPD responses.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Slow growing BCG was associated with higher cytokine responses in monocytes.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Subtle changes in the production of BCG vaccine may influence its immunogenicity.</p> </list-item> </list> </p> </sec> </abstract>