Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction. Issue 17 (21st April 2015) - Gladstone, Rebecca A.
Highlights PCV7 serotype replacement was near complete 5 years after PCV7 introduction. The carriage rate remained stable through out the 5 year period. Serotypes unique to PCV13 significantly decreased by the final winter. Clonal expansion of existing genotypes was primarily responsible for replacement. Continued surveillance is needed to monitor replacement until equilibrium is reached.