The epigenetic/noncoding origin of tumor dormancy. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Crea, Francesco; Nur Saidy, Nur Ridzwan; Collins, Colin C.; Wang, Yuzhuo
• Is Part Of: Trends in molecular medicine. Volume 21:Issue 4(2015)
• Page Start: 206
• Page End: 211
• Publication Date: 2015-04
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2015.02.005
• Languages: English
• ISSNs: 1471-4914

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Cancer stem cells (CSCs) can alternate between dormant and proliferative states.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Dormancy competent CSCs (DCCs) ensure proliferation, drug resistance, and metastasis.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">DCC plasticity is dictated by the epigenetic/noncoding interactome.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Targeting the DCC epigenome may eradicate treatment-resistant cancers.</p> </list-item> </list> </p> </sec> </abstract>